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KMID : 1038220210480030338
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Archives of Plastic Surgery
2021 Volume.48 No. 3 p.338 ~ p.343
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The use of negative-pressure wound therapy over a cultured epithelial autograft for full-thickness wounds secondary to purpura fulminans in an infant
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Goh Benjamin Kah Liang
Chua Alvin Wen Choong
Chew Khong Yik
Kang Gavin Chun-Wui
Chiang Li-Wei
Tan Bien-Keem
Ramachandran Savitha
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Abstract
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Purpura fulminans is a serious condition that can result in severe morbidity in the pediatric population. Although autologous skin grafts remain the gold standard for the coverage of partial- to full-thickness wounds, they have several limitations in pediatric patients, including the lack of planar donor sites, the risk of hemodynamic instability, and the limited graft thickness. In Singapore, an in-house skin culture laboratory has been available since 2005 for the use of cultured epithelial autografts (CEAs), especially in burn wounds. However, due to the fragility of CEAs, negative-pressure wound therapy (NPWT) dressings have been rarely used with CEAs. With several modifications, we report a successful case of NPWT applied over a CEA in an infant who sustained 30% total body surface area full-thickness wounds over the anterior abdomen, flank, and upper thigh secondary to purpura fulminans. We also describe the advantages of using NPWT dressing over a CEA, particularly in pediatric patients.
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KEYWORD
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Negative-pressure wound therapy, Autografts, Epithelium cells, Child, Skin
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